The effects of Tadarise 40 mg can last for up to 36 hours after ingestion. This extended duration of action allows for more spontaneity in sexual activity and provides a wider window of effectiveness. Tadalafil, the active ingredient in Tadarise 40 mg, is a phosphodiesterase type 5 (PDE5) inhibitor. It works by increasing blood flow to the penis during sexual stimulation, which helps men achieve and maintain erections suitable for sexual activity.